Granuloma faciale in a patient with remitting seronegative symmetric synovitis with pitting edema: a case report

Granuloma faciale (GF) is a rare benign chronic inflammatory dermatologic disease which characterized by facial lesions. The diagnosis mainly based on clinical and histopathology findings. It may be resistant to treatments prone relapse. Different treatment modalities include corticosteroid therapy, tacrolimus, cryotherapy surgical methods. We report case of GF in patient with Remitting seronegative symmetric synovitis pitting edema (RS3PE). A male RS3PE presented reddish brown soft nodules over lateral aspects his nose adjacent areas face were diagnosed histologically as GF. He was treated prednisolone, methotrexate clobetasol propionate cream successfully without recurrence. To the best our knowledge this first occurring RS3PE.